Posted on Categories data science, Opinion, Pragmatic Data Science, Statistics, TutorialsTags , , , 5 Comments on Talking about clinical significance

Talking about clinical significance

In statistical work in the age of big data we often get hung up on differences that are statistically significant (reliable enough to show up again and again in repeated measurements), but clinically insignificant (visible in aggregation, but too small to make any real difference to individuals).

An example would be: a diet that changes individual weight by an ounce on average with a standard deviation of a pound. With a large enough population the diet is statistically significant. It could also be used to shave an ounce off a national average weight. But, for any one individual: this diet is largely pointless.

The concept is teachable, but we have always stumbled of the naming “statistical significance” versus “practical clinical significance.”

I am suggesting trying the word “substantial” (and its antonym “insubstantial”) to describe if changes are physically small or large.

This comes down to having to remind people that “p-values are not effect sizes”. In this article we recommended reporting three statistics: a units-based effect size (such as expected delta pounds), a dimensionless effects size (such as Cohen’s d), and a reliability of experiment size measure (such as a statistical significance, which at best measures only one possible risk: re-sampling risk).

The merit is: if we don’t confound different meanings, we may be less confusing. A downside is: some of these measures are a bit technical to discuss. I’d be interested in hearing opinions and about teaching experiences along these distinctions.